Biomagnification of p, p′-DDT and Methoxychlor by Bacteria

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Reductive metabolism of p,p'-DDT and o,p'-DDT by rat liver cytochrome P450.

The in vitro metabolism of p,p'-DDT [1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane], an important environmental pollutant, was examined in rat liver, focusing on reductive dechlorination. When p,p'-DDT was incubated with liver microsomes of rats in the presence of NADPH or NADH, a dechlorinated metabolite, p,p'-DDD [1,1-dichloro-2,2-bis(4-chlorophenyl)ethane], was formed under anaerobic conditi...

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Metabolic Fate of P,p'-ddt (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane)in Rats.

* Inquiries regarding this paper should be addressed to M. S. Dunn, University of California, Los Angeles. The experimental data are from a dissertation submitted by Joseph D. Pinto to the Graduate School of the University of California, Los Angeles, in partial fulfillment of the requirements for the degree of Doctor of Philosophy. The chemical names and structures for DDT and its derivatives, ...

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Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-DDT [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-DDE (2-2-bis(4/chlorophenyl)-1-1-di...

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Effect of single and repeated in vitro exposure of ovarian follicles to o,p'-DDT and p,p'-DDT and their metabolites.

The aim of the presented study was to compare the effect of o,p'-DDT [1,1-dichloro-2,2-bis-(p,p'-chlorophenyl)-ethylene] and p,p'-DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)-ethane] and their metabolites DDE and DDD on estradiol secretion by ovarian follicles, the target organs of environmental estrogens. Theca interna (Tc) and granulosa cells (Gc) were collected from medium size porcine foll...

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ژورنال

عنوان ژورنال: Applied Microbiology

سال: 1973

ISSN: 0003-6919

DOI: 10.1128/aem.26.1.66-71.1973